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. 2014 Dec 16;12(12):e1002024. doi: 10.1371/journal.pbio.1002024

Figure 6. Proposed model for PRD1 procapsid assembly, genome packaging and virus maturation.

Figure 6

(A) Viral membrane-associated proteins are incorporated into the host cytoplasmic membrane, including integral membrane proteins P20 and P22. (B) P20 and P22 form the transmembrane pore in the newly-assembled viral membrane. (C) Various capsid-associated proteins then assemble along the viral membrane to form the viral capsid, while P6/P9 assembles onto the transmembrane pore (P20/P22) and forms the unique packaging complex, which completes the assembly of the procapsid. (D) The newly synthesized viral genomic DNA is then packaged through the unique vertex fueled by the hydrolysis of ATP. (E) Along the genome packaging, the membrane is pushed against the icosahedral protein shell as the last step in the virus maturation.