Table 2. The top 4 shared signaling pathways related to inflammation and shared DEGs in both RA vs. normal and CAD vs. normal subjects.

No.	Shared pathways	Score of pathways (-log(p-value))	Shared DEGs involved in shared pathways	Fold of shared DEGs (-log(p-value))
				RA	CAD
1	IL-8 signaling	6.94	BAX	1.39	1.98
			CXCL1	1.82	1.47
			CXCR1	1.96	1.62
			CXCR2	1.41	1.32
			DEFA1	1.85	2.47
			MMP9	1.90	2.26
			MPO	1.23	1.43
2	Antigen presentation pathway	2.53	HLA-DRB4	1.71	1.99
			HLA-DQA2	1.30	1.51
3	OX40 signaling pathway	2.21	HLA-DRB4	1.71	1.99
			HLA-DQA2	1.30	1.51
4	TREM1 signaling	2.18	CCL2	2.07	1.43
			MPO	1.23	1.43