Table 4. The top functions of predicted upstream regulators networks in RA vs. normal and CAD vs. normal and targets molecules involved in (The molecules in italics are shared predicted upstream regulators and targets in both RA vs. normal and CAD vs. normal groups).

Groups	Predicted upstream regulators	Targets of upstream regulators	Top functions of predicted upstream regulators networks
RA vs. normal	IgG, p38 MAPK, TGFB1, TNF, TREM1, EIF2AK2, IFNG, IFNL1, IL13, IL1B, IRF3	ADA, ADM, ARG1, BIRC5, C1QB, C1QC, CCL2/MCP-1, CTGF, CXCL1, EGR1, EGR2, FN1, GSTA1, HLA-DRB4, IFI27, IFI44L, IFIT1, IFIT3, IFITM3, ISG15, ITGB4, KCNJ2, KCNJ15, MMP9, NOV, RBP1, SNAI1, TNFSF11	Inflammatory response, connective tissue disorders, inflammatory disease.
CAD vs. normal	NF-κB (complex), P38 MAPK, IL1B, TNF	APOBEC3B, CAMP, CCL3, CCL3L1/CCL3L3, CHI3L1, CTGF, EGR2, HLA-DRB4, MMP8, MMP9, PTGES, RBP1	Inflammatory response, hypersensitivity response, cardiovascular disease.