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. 2014 Dec 16;9(12):e115009. doi: 10.1371/journal.pone.0115009

Figure 4. Experiment 2: Locomotor activity in combined DAT/5-HT1B KO mice: short habituation sessions.

Figure 4

(A) Time-course of locomotor activity during the first habituation session in DAT/5-HT1B KO mice (9 genotypes: DAT +/+5-HT1B +/+, DAT −/−5-HT1B +/+, DAT +/+5-HT1B −/−, DAT +/−5-HT1B −/−, DAT −/−5-HT1B +/−, DAT −/−5-HT1B −/−) expressed in terms of total distance traveled. (B) Cocaine-induced locomotor activity in DAT/5-HT1B KO mice expressed as absolute difference from saline (total activity after cocaine injection – total activity after saline injection). Data are represented as mean ± SEM.