Table 4. Odds ratio of renal dysfunction for decrease in serum bilirubin and hypobilirubinemia.
| Odds ratio (95% confidence interval) | ||||
| CKD stage (mL/min/1.73 m2) | Stages 1+2 | Stage 3a | Stage 3b | Stage 4 |
| eGFR by CKD-EPI equation | ≥60.0 | 59.9−45.0 | 44.9−30.0 | <30.0 |
| Characteristic N = 1,050 | N = 554 | N = 228 | N = 154 | N = 114 |
| Serum bilirubin (per quartile) | 1.00 (referent) | 0.96 (0.83−1.11) | 0.82 (0.69−0.97) | 0.62 (0.51−0.76) |
| Non-adjusted | 1.00 (referent) | 0.98 (0.84−1.13) | 0.86 (0.73−1.03) | 0.66 (0.53−0.80) |
| Gender & age-adjusted | 1.00 (referent) | 0.96 (0.82−1.12) | 0.93 (0.75−1.15) | 0.62 (0.46−0.83) |
| Multivariate-adjusted* | ||||
| Hypobilirubinemia | 1.00 (referent) | 1.10 (0.76−1.60) | 1.54 (1.03−2.31) | 3.25 (2.13−4.94) |
| (First quartile, <0.52 mg/dL) | 1.00 (referent) | 1.07 (0.74−1.57) | 1.29 (0.84−1.98) | 2.97 (1.91−4.61) |
| Non-adjusted | 1.00 (referent) | 1.12 (0.75−1.68) | 1.03 (0.61−1.74) | 3.52 (1.88−6.59) |
| Age & gender-adjusted | ||||
| Multivariate-adjusted* | ||||
*Models adjusted for gender, age, body mass index, smoking status, diastolic blood pressure, antihypertensive medication, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, antidyslipidemic medication, fasting blood glucose, antidiabetic medication, and uric acid. Data for triglycerides, and fasting plasma glucose were skewed and log-transformed for analysis. Serum bilirubin: quartile-1, 0.21−0.51; quartile-2, 0.52−0.71; quartile-3, 0.72−0.99; quartile-4, 1.00−2.00 mg/dL.