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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Metabolism. 2014 Sep 28;64(1):13–23. doi: 10.1016/j.metabol.2014.09.010

Fig. 2.

Fig. 2

Leptin signaling pathways and cellular leptin resistance. Schematic drawing of signaling pathways induced via the long form leptin receptor (LepRb). PI3K = phosphatidylinositol-3-kinase; IRS = insulin receptor substrate; JAK2 = janus kinase-2; ER = endoplasmatic reticulum, STAT = signal-transducer-and-activator-of-transcription; SOCS-3 = suppressor-of-cytokine-signaling-3; PTP1B = phosphotyrosine phosphatase 1B; TSC1/2 = tuberous-sclerosis1/2; mTOR = mammalian-target-of-rapamycin; pS6 = phosphorylated ribosomal protein S6; AMPK = AMP-activated protein kinase; ACC = acetyl-CoA carboxylase; SHP-2 = src-homology-2 containing phosphotyrosine phosphatase 2; MAPK = mitogen-activated-protein-kinase.

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