Table 1.

Changes in heart rate following an acute injection of propranolol or atropine in normotensive rats and rats made hypertensive by chronic infusion of L-NAME or Ang II.

Groups/treatment	Propranolol (Δ bpm)	Atropine (Δ bpm)
Vehicle + SHU-9119
Control	−70±8	46±4
SHU-9119	−27±4*	88±11*
L-NAME + SHU-9119
Control	−55±12	34±8
L-NAME	−59±14	53±4*
L-NAME + SHU-9119	−33±13#	55±8*
Ang II + SHU-9119
Control	−61±8	51±4
Ang II	−57±21	69±15*
Ang II + SHU-9119	−15±8*†	74±13*

Values represent mean + SEM. Propranolol and atropine were injected on the last day of the control period, day 7 of L-NAME or Ang II infusion, and again on day 17 of L-NAME or Ang II infusion (e.g. day 10 of SHU-9119 treatment).

^*indicates p<0.05 vs. control values;

^#indicates p<0.05 vs. L-NAME alone;

^†indicates p<0.05 vs. Ang II alone.