Table 2.
Comparison of liver and liver parenchymal volumes and predicted liver volumes using a standardized equation versus liver volumes for healthy controls.
| Liver Volume (mL) | Liver Parenchymal Volume (mL) | |||||
|---|---|---|---|---|---|---|
| Normal living liver transplant donors | HALT (predicted) | HALT (observed) | HALT (all patients) | HALT (patients with cysts) | HALT (patients without cysts) | |
| Men | ||||||
| mean±std (n) | 1772±393 (11) | 1875 ±238 (274) | 2022±749 (267) | 1900±344 (267) | 1892 ±331 (185) | 1918 ±372 (82) |
| P value vs. normal donors | ------ | ------ | <.0001* | <.0001* | <.0001* | <.0001* |
| P value vs. predicted LV | ------ | ------ | .0004** | .6046** | .7931** | .5969** |
| Women | ||||||
| mean±std (n) | 1495±357 (21) | 1511±235 (271) | 1905±860 (267) | 1594±337 (267) | 1555 ±289 (210) | 1735 ±448 (57) |
| P value vs. normal donors | ------ | ------ | <.0001* | <.0001* | <.0001* | <.0001* |
| P value vs. predicted LV | ------ | ------ | <.0001** | <.0001** | .0001** | <.0663** |
To determine predicted LV (reported as “HALT predicted”) we used the Vauthey formula, a validated equation for the estimation of standard liver volume in the Caucasian population (LV in mL = −794.41+1,267.28 × BSA in m2).22 Note values in this table are unadjusted for height to permit between group comparisons.
One-sample t test compared to healthy controls.
Paired t test compared to predicted LV.
Normal liver transplant donor MRI-derived LVs were obtained at the University of Pittsburgh from patients considering liver donation. Similar results were obtained using LVs from a CT-based study from another published healthy population (males 1710±288 mL (41) and females 1411±263 mL (36)) 20