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. Author manuscript; available in PMC: 2016 Jan 22.
Published in final edited form as: Neuroscience. 2014 Nov 4;0:678–684. doi: 10.1016/j.neuroscience.2014.10.056

Figure 2. Effect of intravenous methionine and homocysteine on muscle hyperalgesia and stimulus-dependent hyperalgesia produced by ischemia-reperfusion injury.

Figure 2

Exposure to either hind limb vibration (A) or eccentric exercise (B) produced a marked decrease in mechanical nociceptive threshold in the ipsilateral gastrocnemius muscle. Intravenous administration of either methionine (1 mg/kg) or homocysteine (3 mg/kg) prevented this hyperalgesia when evaluated 30 min and 3 h after administration.