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. Author manuscript; available in PMC: 2015 Dec 30.
Published in final edited form as: Int J Pharm. 2014 Oct 22;477(0):334–343. doi: 10.1016/j.ijpharm.2014.10.022

Fig. 6.

Fig. 6

Inhibition of intracellular growth of S. Typhi in macrophages by AR-12/MPs. (A) Time-dependent effects of 20µM AR-12/MPs on intracellular growth of S. Typhi. hMDMs were incubated with S. Typhi for 2h. After the removal of extracellular bacteria, the infected cells were treated with 20µM AR-12/MPs. The bacterial load (CFU) was determined by plating cell lysates. (B) AR-12/MPs retained ability to enhance the clearance of S. Typhi by hMDMs. Infected hMDMs were treated with different doses of unencapsulated AR-12 or AR-12/MPs. The bacterial load (CFU) was determined at 22h post treatment. AR-12 = un-encapsulated drug, AR-12/MPs = encapsulated AR-12, and AP = empty Ace-DEX microparticles. The data are presented as average ± SD (P ≤ 0.05). AR-12 demonstrates hMDM cytotoxicity at a concentration ≥ 10µM.