Figure 2.

QTL mapping of clinical markers of cardiovascular disease in 6-wk-old DO mice at baseline. Genome-wide QTL scans for loci affecting plasma levels of triglycerides (A), total cholesterol (B), and glucose (C) in the DO population at baseline. Chromosomes 1 through X are represented numerically on the x-axis, and the y-axis represents the LOD score. The relative width of the space allotted for each chromosome reflects the relative length of each chromosome. Mice were maintained on a synthetic diet for 2 wk and then phenotyped for plasma clinical chemistries at 6 wk of age. Colored lines show permutation-derived significance thresholds (N = 1000) at P = 0.05 (LOD = 7.57, shown in red), P = 0.10 (LOD = 7.17, shown in orange), and P = 0.63 (LOD = 5.79, shown in yellow). QTL, quantitative trait locus; DO, Diversity Outbred; LOD, log of the odds ratio.