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. 2014 Oct 23;4(12):2353–2363. doi: 10.1534/g3.114.014704

Figure 7.

Figure 7

Cis-eQTL for hepatic Apobec1 short and long isoforms in the DO mice. Genome-wide QTL scan for eQTL regulating expression of the short (A) and long (B) Apobec1 isoforms in the DO mice. Chromosomes 1 through X are represented numerically on the x-axis, and the y-axis represents the LOD score. The relative width of the space allotted for each chromosome reflects the relative length of each chromosome. Colored lines show permutation-derived significance thresholds (N = 1000) at P = 0.05 (LOD = 7.57, shown in red), P = 0.10 (LOD = 7.17, shown in orange), and P = 0.63 (LOD = 5.79, shown in yellow). The eight coefficients of the QTL model show the effects on the phenotype contributed by each founder haplotype on Chromosome 6 for mapping of the short (C) and long (D) isoforms of Apobec1. Shading identifies the 95% Bayesian credible interval around the peak. eQTL, expression quantitative trait loci; DO, Diversity Outbred; LOD, log of the odds ratio.