. Author manuscript; available in PMC: 2015 Dec 28.

Published in final edited form as: J Control Release. 2014 Oct 24;0:272–286. doi: 10.1016/j.jconrel.2014.10.016

Table 3.

MTD of DOX and DOX-loaded nanomicellar formulations

Formulations	Does (mg/kg)	Animal death	Weight loss (%)
DOX	5	0/3	2.2
	10	0/3	7.8
	15	2/3	N/A
DOX-loaded PEG_5K-VE₂	5	0/3	0.9
	10	0/3	−1.8
	15	0/3	3.9
	20	0/3	6.2
	30	3/3	N/A
DOX-loaded PEG_5K-Fmoc-VE₂	10	0/3	−2.2
	15	0/3	0.2
	20	0/3	−1.3
	25	0/3	3.5
	30	0/3	7.4
	35	2/3	N/A