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Tumor growth inhibition rate (IR) in 4T1.2 tumor bearing mice.
| Different DOX formulations | IR (%) |
|---|---|
| Doxil 10 mg/kg | 62.24 |
| PEG5K-VE2/DOX 10 mg/kg | 67.73 |
| PEG5K-Fmoc-VE2/DOX 10 mg/kg | 82.63 |
| PFG5K-Fmoc-VE2/DOX 20 mg/kg | 89.77 |
IR (%) = (1 − relative tumor volume in the treated group ÷ relative tumor volume in the saline group) × 100%
IR (%) was calculated based on the RTV on day 15 (Mice in saline group died after day 15. Mice in DOX group died after third injection due to severe toxicity)
