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Schematic diagram shows Cdk5 activating protein p39 directly links muskelin to myosin II and thus to stress fibers, and indicates that p39 has a dual role in cytoskeletal regulation. It is an integral subunit of Cdk5 kinase as well as acting as an adaptor protein to recruit muskelin and other muskelin-associated cytoskeletal proteins, which may regulate MRLC phosphorylation, stress fibers formation, and cytoskeletal contraction.
