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Dusp1 deficiency enhances 4NQO-induced disease progression. A, Schematic of 4NQO-induced model of oral cancer with representative image of an oral lesion at 28 weeks. B, Disease burden, estimated by weight change. n = 37 per group, p <0.001. C, Individual tumor burden n= 14–15, p = 0.0032. D, Neoplastic progression of tumors, scored on the indicated histologic scale.
