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. Author manuscript; available in PMC: 2015 Jun 11.
Published in final edited form as: Nature. 2014 Sep 28;516(7530):246–249. doi: 10.1038/nature13788

Extended Data Figure 10. Dietary modulation of the intestinal microbiota composition drives autoinflammatory osteomyelitis by setting proIL-1β levels available for maturation by caspases 1 and 8.

Extended Data Figure 10

Proposed model highlighting how dysbiosis and processing of IL-1β by caspase-1/8 contribute to the development of inflammatory bone disease.