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. 2014 Dec 11;1(4):e47. doi: 10.1212/NXI.0000000000000047

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© 2014 American Academy of Neurology

This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

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Meta-analysis showing the influence of HLA-DRB1*13/*14 (A) and HLA-DRB1*15 (B) in the development of anaphylactic/anaphylactoid reactions to natalizumab in the different study cohorts. Forest plots showing the overall data and data after eliminating heterogeneity by removing the Spanish cohort. CI = confidence interval; HLA = human leukocyte antigen; HN+/HN− = patients who developed and did not develop anaphylactic/anaphylactoid reactions, respectively; M–H = Mantel-Haenszel.