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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2014 Oct 22;4(1):17–32. doi: 10.1002/wdev.161

Fig. 4. Signalling centers instructing telencephalon.

Fig. 4

Frontolateral view of the telencephalon indicating its distinct signalling centers important for regional differentiation in relation to other developing head structures: the ventral center secreting SHH (red), the rostral center secreting FGF8 (blue), and the dorsal center secreting BMPs and Wnt (green). Cross-regulation between the rostral, dorsal, and ventral signalling centres plays an essential role in patterning the early telencephalon. Cx, cortex; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; S, septum (reprinted with permission from Hoch et al, 2009146, Elsevier).