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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Cancer Res. 2014 Nov 6;74(24):7371–7382. doi: 10.1158/0008-5472.CAN-14-0794

Figure 2.

Figure 2

The regulation of proliferation and apoptosis by Mig-6 overexpression when Pten is mutated. (A) Immunohistochemical analysis of phospho-histone H3 as a proliferation marker in uteri of Ptend/d (a) and Mig-6overPtend/d (b) mice at 2 months of age. (B) Quantification of phospho-histone H3 positive cells in epithelial cells. (C) The regulation of the hypoxia-inducible factor 1 in Mig-6overPtend/d mice. Real-time RT-PCR analysis of Hif1a, Slc2a1, Nos2, Egln3, and Mmp15 was performed on uteri of from control, Mig-6over, Ptend/d and Mig-6overPtend/d mice at 2 and 3 months of age. The results represent the mean ± SEM. * p<0.05, ** p<0.01, *** p<0.001.