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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Cancer Res. 2014 Nov 6;74(24):7371–7382. doi: 10.1158/0008-5472.CAN-14-0794

Figure 4.

Figure 4

The expression of phospho-ERK1/2 is significantly reduced in Mig-6overPtend/d mice. (A) Immunohistochemical analysis of phospho-ERK1/2 in the uteri of Ptend/d and Mig-6overPtend/d mice at 2 (a and b) and 3 (c and d) months of age. (B) Western blot analysis of phospho-ERK1/2, ERK1/2, and ACTIN in the uteri of Ptend/d and Mig-6overPtend/d mice at 2 and 3 months of age. Equal amounts of protein were subjected to SDS-PAGE and Western blot analysis. (C) The expression of ERK1/2 target genes. Real-time RT-PCR analysis of Fos, Junb, Serpine and F3 was performed on uteri of from control, Mig-6over, Ptend/d and Mig-6overPtend/d mice at 2 and 3 months of age. The results represent the mean ± SEM. * p<0.05, ** p<0.01.