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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Oral Oncol. 2014 Oct 25;51(1):16–23. doi: 10.1016/j.oraloncology.2014.10.004

Table 2.

Factors/Receptors Implicated in Perineural Cancer Growth

FACTOR PRIMARY RECEPTOR OTHER RECEPTORS IMPLICATED CANCER(S) REFERENCE
Brain-derived neurotrophic factor (BDNF) TrkB Nerve growth factor receptor (NGFR) ACC, pancreatic, gastric, SCC [49-52, 62]
Nerve growth factor (NGF) TrkA NGFR Pancreatic, breast prostate, SCC, ACC, lung, breast, esophageal [42, 56-58, 106, 107]
Neurotrophin-3 (NT-3) TrkC TrkA, TrkB, NGFR Pancreatic [62]
Neurotrophin-4 (NT-4) TrkB NGFR Pancreatic [50]
Glial cell-line derived neurotrophic factor (GDNF) family, including neurturin, artemin, and persephin GFRα1, GFRα2, GFRα3, GFRα4, RET Pancreatic, bile duct carcinoma [12, 64, 66, 68-74, 108]
Neural cell adhesion molecule (NCAM) NCAM Pancreatic, basal cell carcinoma, cutaneous SCC, ACC [12, 61, 79, 109]
Substance P (SP) Tachykinin receptor l (TACR/NK-1R) Pancreatic [45]
Chemokines Head and neck, pancreatic, prostate, breast, and more [12, 93, 97, 101, 102]

ACC: salivary gland adenocystic carcinoma SCC: Squamous cell carcinoma