Table 2.
Baseline characteristics according to the tertiles of fluorescent oxidation products
| Tertile 1 | Tertile 2 | Tertile 3 | P for trend | |
|---|---|---|---|---|
| FlOP_360 | ||||
| Range (FI/ml) | < 192 | ≥ 192; < 255 | ≥ 255 | --- |
| N | 332 | 331 | 333 | --- |
| Age (years) | 64.3 (2.5) | 64.3 (2.4) | 64.6 (2.5) | 0.189 |
| Body mass index (kg/m2) | 26.6 (4.9) | 25.4 (4.4) | 25.0 (4.5) | < 0.001 |
| Alcohol intake (g/day)* | 0 (0, 3.5) | 1.5 (0, 8.3) | 1.5 (0, 8.3) | < 0.001 |
| Physical activity (MET-hours/week)* | 10.2 (3.9, 20.2) | 10.2 (4.0, 23.5) | 11.8 (4.0, 24.6) | 0.054 |
| Total calcium intake (mg/day)* | 975 (675, 1327) | 963 (679, 1338) | 997 (650, 1411) | 0.207 |
| Total vitamin D intake (IU/day)* | 286 (184, 514) | 303 (197, 549) | 324 (170, 540) | 0.203 |
| Total carotenoid intake (1000 IU/day)* | 8.5 (6.1, 12.1) | 9.5 (6.6, 13.4) | 9.0 (6.1, 12.8) | 0.632 |
| Fasting status (≥ 8 hours; n, %) | 265 (80%) | 258 (78%) | 227 (68%) | 0.020 |
| History of osteoporosis (n, %) | 18 (5.4%) | 17 (5.1%) | 17 (5.1%) | 0.874 |
| History of hypertension (n, %) | 77 (23%) | 72 (22%) | 107 (32%) | 0.002 |
| Current smokers (n, %) | 24 (7%) | 54 (16%) | 95 (29%) | < 0.001 |
| Past smokers (n, %) | 120 (36%) | 146 (44%) | 129 (39%) | 0.840 |
| Hormone therapy (n, %)£ | 112 (34%) | 130 (39%) | 134 (40%) | 0.128 |
| Prior fracture (n, %) | 8 (2.4%) | 15 (4.5%) | 11 (3.3%) | 0.761 |
|
| ||||
| FlOP_320 | ||||
| Range (FI/ml) | < 335 | ≥ 335; < 546 | ≥ 546 | --- |
| N | 331 | 331 | 334 | --- |
| Age (years) | 64.6 (2.5) | 64.1 (2.5) | 64.5 (2.5) | 0.006 |
| Body mass index (kg/m2) | 25.9 (4.4) | 25.6 (4.7) | 25.4 (4.7) | 0.396 |
| Alcohol intake (g/day)* | 0.9 (0, 5.5) | 0.9 (0, 6.7) | 1.1 (0, 7.6) | 0.208 |
| Physical activity (MET-hours/week)* | 10.3 (5.2, 20.7) | 11.6 (3.5, 24.0) | 10.4 (3.9, 22.4) | 0.164 |
| Total calcium intake (mg/day)* | 951 (679, 1314) | 930 (664, 1317) | 1021 (669, 1415) | 0.983 |
| Total vitamin D intake (IU/day)* | 271 (179, 475) | 302 (192, 533) | 348 (193, 590) | 0.034 |
| Total carotenoid intake (1000 IU/day)* | 8.5 (6.1, 12.4) | 9.3 (6.6, 13.2) | 9.2 (6.5, 12.8) | 0.626 |
| Fasting status (≥ 8 hours; n, %) | 284 (86%) | 242 (73%) | 224 (67%) | 0.002 |
| History of osteoporosis (n, %) | 14 (4.2%) | 18 (5.4%) | 20 (6.0%) | 0.469 |
| History of hypertension (n, %) | 72 (22%) | 78 (24%) | 106 (32%) | 0.578 |
| Current smokers (n, %) | 28 (8%) | 68 (21%) | 77 (23%) | < 0.001 |
| Past smokers (n, %) | 139 (42%) | 133 (40%) | 123 (37%) | 0.636 |
| Hormone therapy (n, %)£ | 123 (37%) | 125 (38%) | 128 (38%) | 0.873 |
| Prior fracture (n, %) | 8 (2.4%) | 9 (2.7%) | 17 (5.1%) | 0.806 |
|
| ||||
| FlOP_400 | ||||
| Range (FI/ml) | < 52.9 | ≥52.9; < 72.9 | ≥ 72.9 | --- |
| N | 333 | 332 | 331 | --- |
| Age (years) | 64.5 (2.5) | 64.2 (2.5) | 64.4 (2.5) | 0.620 |
| Body mass index (kg/m2) | 26.2 (5.0) | 25.6 (4.4) | 25.2 (4.5) | 0.062 |
| Alcohol intake (g/day)* | 0.9 (0, 3.5) | 1.1 (0, 6.7) | 1.5 (0, 11.0) | < 0.001 |
| Physical activity (MET-hours/week)* | 10.7 (4.0, 20.4) | 10.2 (3.9, 21.6) | 11.7 (4.0, 25.0) | 0.263 |
| Total calcium intake (mg/day)* | 1045 (691, 1353) | 954 (665, 1357) | 924 (641, 1313) | 0.046 |
| Total vitamin D intake (IU/day)* | 313 (203, 535) | 303 (182, 548) | 293 (181, 529) | 0.015 |
| Total carotenoid intake (1000 IU/day)* | 9.5 (6.6, 14.1) | 9.0 (6.1, 12.8) | 8.5 (6.1, 11.9) | 0.842 |
| Fasting status (≥ 8 hours; n, %) | 275 (83%) | 238 (72%) | 237 (72%) | 0.155 |
| History osteoporosis (n, %) | 16 (4.8%) | 16 (4.8%) | 20 (6.0%) | 0.152 |
| History of hypertension (n, %) | 78 (23%) | 73 (22%) | 105 (32%) | 0.001 |
| Current smokers (n, %) | 10 (3%) | 44 (13%) | 119 (36%) | < 0.001 |
| Past smokers (n, %) | 129 (39%) | 146 (44%) | 120 (36%) | 0.210 |
| Hormone therapy (n, %)£ | 134 (40%) | 120 (36%) | 122 (37%) | 0.739 |
| Prior fracture (n, %) | 16 (4.8%) | 11 (3.3%) | 7 (2.1%) | 0.980 |
Abbreviations: FlOP = Fluorescent oxidation products, FI = Fluorescent intensity units, METs = Metabolic equivalent hours.
£
Postmenopausal hormone therapy.
Variables with normal distribution are shown in mean (standard deviation), unless otherwise specified.
*
Variables with skew distribution are shown in median (inter-quartile range).