Table 5. Multiple linear regression analysis of factors associated with neurocognitive concerns measured by the revised CCSS-NCQ.

	Memory		Task efficiency		Organization		Emotional regulation
Variables	Parameter estimate	p	Parameter estimate	p	Parameter estimate	p	Parameter estimate	p
Age at diagnosis
0-2	0.021	0.890	-0.039	0.803	-0.182	0.245	0.142	0.243
3-5	-0.082	0.532	0.042	0.752	-0.157	0.241	-0.003	0.980
6-10	-0.092	0.485	0.025	0.853	-0.170	0.206	0.045	0.672
11-15	-0.084	0.521	0.046	0.732	-0.194	0.148	0.021	0.838
16-20	Ref		Ref		Ref		Ref
Cranial radiation
Yes	-0.245	0.001	-0.333	<0.001	-0.033	0.655	-0.191	0.009
No	Ref		Ref		Ref		Ref
Intravenous methotrexate
Yes	-0.110	0.140	-0.056	0.467	-0.054	0.479	-0.078	0.296
No	Ref		Ref		Ref		Ref
Intrathecal methotrexate
Yes	0.032	0.731	-0.008	0.934	-0.049	0.599	-0.131	0.152
No	Ref		Ref		Ref		Ref
High dose methotrexate
Yes	0.102	0.213	0.160	0.058	0.102	0.221	0.184	0.028
No	Ref		Ref		Ref		Ref
Relapse
Yes	0.182	0.027	0.103	0.221	-0.050	0.553	0.198	0.017
No	Ref		Ref		Ref		Ref
Current age
17-24	0.178	0.141	-0.048	0.698	0.185	0.135	-0.003	0.983
25-29	0.095	0.392	-0.041	0.718	0.104	0.360	-0.065	0.619
30-34	0.107	0.314	0.089	0.419	0.117	0.283	-0.143	0.281
35-39	-0.057	0.575	0.038	0.717	0.030	0.774	-0.036	0.796
40+	Ref		Ref		Ref		Ref
Sex
Female	-0.309	<0.001	-0.310	<0.001	-0.139	0.031	-0.467	<0.001
Male	Ref		Ref		Ref		Ref
Race
Other	0.103	0.247	0.094	0.305	-0.194	0.148	0.047	0.600
White	Ref		Ref		Ref		Ref