Table 2.

Left/more affected STN - sensorimotor cortex resting-state functional connectivity results.

Comparison	Brain region(s)	Side	Size (mm3)	MNI coordinates (peak)			t-value
				x	y	z
Mean resting-state functional connectivity
Controls	PMv, M1	R	2008	−44	−14	28	6.07
	Pre-SMA, SMA	R	1872	−6	6	56	5.22
	SMA, PMd	L	1352	22	12	56	5.04
	PMd	R	952	−32	2	60	6.29
	M1	R	936	−2	−40	72	−4.82
	PMv	L	656	46	12	32	4.83
	PMv	R	496	−46	16	28	4.49
De novo PD	PMv, PMd	L	2944	52	6	42	5.71
	SMA, Pre-SMA	L	1600	10	0	62	5.01
	PMv	R	1008	−54	6	16	4.87
	S1	L	960	54	−32	58	5.33
Mod PD	Pre-SMA	L	1136	4	20	56	4.96
	PMd	L	888	44	−2	62	4.53
	S1, M1	L	512	38	−32	54	4.08
	PMd	R	472	−28	8	48	4.60
Between-group differences
De novo PD > Controls	M1, S1	L	1128	46	−24	66	−4.28
Mod PD > Controls	M1, S1	L	632	26	−30	52	−3.75
De novo PD > Mod PD	PMv	L	544	44	4	34	3.58

Significance set at P < 0.05 (corrected using 3dClustSim in AFNI). Results are given in MNI space. PD, Parkinson’s disease; Mod, moderate; Corr, correlation; M1, primary motor cortex; S1, sensorimotor cortex; PMd, dorsal premotor cortex; PMv, ventral premotor cortex; SMA, supplementary motor area; Pre-SMA, pre-supplementary motor area; L, left; R, right.