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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Hypertension. 2014 Nov 3;65(1):153–160. doi: 10.1161/HYPERTENSIONAHA.114.04038

Figure 3.

Figure 3

Calcium mediates the inhibitory effect of the D4 receptor on AT1 receptor expression in WKY RPT cells.

A. Effect of D4 receptor agonist, PD168077 (10-6M/24hrs) and calcium channel blocker, nicardipine (10-6M/24hrs), on AT1 receptor protein expression in WKY RPT cells. The cells were incubated with the indicated reagents. Results are expressed as the ratio of AT1 receptor and α–actin densities (n = 6, *P<0.05 vs. others).

B. Effect of a D4 receptor agonist, PD168077 (10-6M/24hrs), on AT1 receptor expression in WKY RPT cells incubated in medium with or without calcium. Results are expressed as the ratio of AT1 receptor and α–actin densities (n = 5, *P<0.05 vs. others).