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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Cancer Res. 2014 Oct 17;74(24):7285–7297. doi: 10.1158/0008-5472.CAN-14-1240

Figure 1.

Figure 1

Impact of RAGE ablation in tumor microenvironment on glioma growth. A, Kaplan-Meier plots (top panel) and tumor luciferase activity (lower panel) in wild-type (WT) and RAGE knockout (Ager−/−) mice implanted with either intracranial GL261 or KLuc gliomas (n=7-8 mice/group, MS: median survival). B, Despite improvement in survival, tumor size (two weeks after implantation) was similar in WT and Ager−/− mice. Cross sections through the largest tumor area were used for size calculations (n=4 mice/group ± SD). C, Except for increased central necrosis in the GL261 tumors in Ager−/− mice, tumor histology and invasion pattern was similar in both strains. Experimental results are representative of three separate experiments.