Table 3.

The association of novel risk markers with adjusted odds* of significant carotid intima media thickness (>1 mm) and coronary calcification (Agatston Score >100), overall and by race

Marker		Significant carotid intima media thickness (>1 mm)			Significant coronary artery calcification (Agatston Score >100)
		N available	OR (95 % CI) per 1-SD higher level	χ 2	N available	OR (95 % CI) per 1-SD higher level	χ 2
a) Overall association
sdLDL		776	1.43(1.14,1.79)	9.7	767	0.92(0.77,1.10)	0.8
CD40L		531	0.96(0.71,1.29)	0.1	223	1.06(0.74,1.52)	0.1
Log-CRP		725	1.00(0.77,1.30)	0.0	716	1.05(0.84,1.30)	0.2
Log-IL-6		711	1.20(0.93,1.54)	2.0	704	1.28(1.04,1.58)	5.2
Endostatin		565	0.90(0.69,1.16)	0.7	240	1.04(0.75,1.44)	0.0
sICAM-1		648	0.84(0.63,1.12)	1.4	654	1.07(0.88,1.31)	0.5
Race	Variable	Significant carotid intima media thickness (>1 mm)			Significant coronary artery calcification (Agatston Score >100)
		N available	OR (95 % CI) per 1-SD higher level	χ 2	N available	OR (95 % CI) per 1-SD higher level	χ 2
b) Association by race
White	sdLDL	503	1.36(1.01,1.83)	4.2	410	0.98(0.78,1.24)	0.0
	CD40L	349	0.89(0.62,1.28)	0.4	133	1.16(0.77,1.74)	0.5
	Log-CRP	473	1.03(0.72,1.46)	0.0	380	1.03(0.77,1.39)	0.1
	Log-IL-6	466	1.21(0.88,1.66)	1.3	375	1.19(0.91,1.56)	1.6
	Endostatin	368	0.91(0.60,1.37)	0.2	144	0.93(0.59,1.45)	0.1
	sICAM-1	405	0.99(0.63,1.55)	0.0	346	1.06(0.79,1.41)	0.1
Black	sdLDL	273	1.73(1.19,2.50)	8.3	357	0.84(0.63,1.12)	1.4
	CD40L	182	1.16(0.65,2.08)	0.3	82	1.06(0.35,3.16)	0.0
	Log-CRP	252	0.95(0.63,1.43)	0.1	336	1.04(0.74,1.45)	0.0
	Log-IL-6	245	1.21(0.79,1.84)	0.8	329	1.40(0.98,1.98)	3.5
	Endostatin	197	0.84(0.58,1.20)	0.9	88	1.57(0.80,3.07)	1.7
	sICAM-1	230	0.75(0.51,1.11)	2.1	308	1.06(0.79,1.41)	0.2

*Adjustment for age, sex, race, systolic blood pressure, smoking status, diabetes, body mass index, total cholesterol, HDL-c, triglycerides and fasting glucose

Total cholesterol was not adjusted for when assessing the association of sdLDL