Histologic score of renal I/R injury. The extent of damage at the corticomedullary junction was graded with a modified schema as described in Materials and Methods. The score represents the percentage of morphologic alterations as follows: 1, <10%; 2+, 10–25%; 3+, 26–75%; 4+, >75%. Data are presented as mean ± standard error (n=3–4/group). *P < 0.05 vs. control; #P < 0.05 vs. vehicle. Con, control; Veh, vehicle; R405, RSVA405; and R314, RSVA314.