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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Hypertension. 2014 Oct 13;65(1):130–139. doi: 10.1161/HYPERTENSIONAHA.114.04473

Figure 4.

Figure 4

(A) NS309-mediated relaxing responses in endothelium-intact (+E, open symbols) and endothelium-denuded (-E, closed symbols) MAs derived from wt (circles), Trx-Tg (upward triangles) and dnTrx-Tg (downward triangles) mice. (B) NS309-mediated relaxing responses in MAs treated with L-NAME (100 μmol/L) and INDO (10 μmol/L) from wt (circles), Trx-Tg (upward triangles) and dnTrx-Tg (downward triangles) mice. (C) Effect of IK1 channel activator SKA-31 (1 μmol/L) in MAs treated with L-NAME and INDO followed by contraction with PHE and cumulative concentrations to ACh. MAs were isolated from wt (circles), Trx-Tg (upward triangles) and dnTrx-Tg (downward triangles) mice. Values are means ± SEM (n=8–10 mice). * P< 0.05 Trx-Tg compared with wt and dnTrx-Tg, # P< 0.05 dnTrx-Tg compared with wt and Trx-Tg.