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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Hypertension. 2014 Oct 13;65(1):130–139. doi: 10.1161/HYPERTENSIONAHA.114.04473

Figure 5.

Figure 5

NS309-mediated relaxing responses in MAs derived from wt (circles), Trx-Tg (upward triangles) and dnTrx-Tg (downward triangles) mice. MAs were either incubated with L-NAME (100 μmol/L), INDO (10 μmol/L) and the IK1 blocker TRAM-34 (A), or the SK3 channel blocker UCL-1684 (B) or the combined presence of TRAM-34 and UCL- 1684 (C). Inserts: shift in sensitivity (ΔpEC50) for NS309 caused by IK1 inhibition by TRAM-34 for wt (white bars), Trx-Tg (blue bars), and dnTrx-Tg (red bars) mice. Values are means ± SEM (n=8–10 mice). * P< 0.05 Trx-Tg compared with wt or dnTrx-Tg.