Table 3.
HRs for Death by Diabetes Treatment Among Patients With Pancreatic Cancer With Long-Term Diabetes
| Cohort | No Diabetes HR | Oral Medication |
Insulin Injection |
||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| NHS/HPFS | |||||||
| Person-months | 8,544 | 235 | 42 | ||||
| No. of patient cases | 825 | 43 | 13 | ||||
| No. of deaths | 793 | 41 | 13 | ||||
| Median OS, months | 5 | 3 | 1 | ||||
| Age adjusted | 1.0 | 1.45 | 1.06 to 1.99 | .02 | 2.10 | 1.21 to 3.66 | .009 |
| Multivariable adjusted* | 1.0 | 1.51 | 1.10 to 2.08 | .01 | 2.10 | 1.20 to 3.68 | .009 |
| Multivariable adjusted† | 1.0 | 1.71 | 1.24 to 2.36 | .001 | 1.60 | 0.91 to 2.79 | .10 |
| DFCI | |||||||
| Person-months | 4,185 | 225 | 241 | ||||
| No. of patient cases | 265 | 19 | 26 | ||||
| No. of deaths | 179 | 16 | 19 | ||||
| Median OS, months | 13 | 12 | 8 | ||||
| Age adjusted | 1.0 | 1.37 | 0.81 to 2.31 | .24 | 1.53 | 0.94 to 2.48 | .08 |
| Multivariable adjusted* | 1.0 | 1.48 | 0.87 to 2.51 | .15 | 1.72 | 1.05 to 2.80 | .03 |
| Multivariable adjusted† | 1.0 | 1.38 | 0.81 to 2.34 | .24 | 1.79 | 1.10 to 2.94 | .02 |
Abbreviations: DFCI, Dana-Farber Cancer Institute; HPFS, Health Professionals Follow-Up Study; HR, hazard ratio; NHS, Nurses' Health Study; OS, overall survival.
*
Adjusted for age at diagnosis (continuous), sex (male or female), race/ethnicity (white, black, other, or unknown), smoking status (never, past, current, or missing), and year of diagnosis (continuous).
†
Further adjusted for stage at diagnosis (localized, locally advanced, metastatic, or unknown).