Table A4.
Recurrence and HRs for BRAF V600E Mutation–Positive Versus –Negative Patients With PTC (all types) in Various Age and Sex Groups
| Patient Age (years) | Recurrence |
HR | 95% CI | |||
|---|---|---|---|---|---|---|
|
BRAF Mutation Positive |
BRAF Mutation Negative |
|||||
| No. | % | No. | % | |||
| All PTCs | ||||||
| All patients | ||||||
| All ages | 213 of 1,017 | 20.9 | 125 of 1,082 | 11.6 | 1.82 | 1.46 to 2.28 |
| < 45 | 75 of 443 | 16.9 | 69 of 576 | 12.0 | 1.37 | 0.99 to 1.91 |
| ≥ 45 | 138 of 574 | 24.0 | 56 of 506 | 11.1 | 2.20 | 1.61 to 3.00 |
| ≥ 60 | 80 of 251 | 31.9 | 31 of 195 | 15.9 | 1.84 | 1.22 to 2.79 |
| Women | ||||||
| All ages | 133 of 767 | 17.3 | 86 of 848 | 10.1 | 1.72 | 1.31 to 2.26 |
| < 45 | 50 of 351 | 14.2 | 50 of 468 | 10.7 | 1.33 | 0.90 to 1.98 |
| ≥ 45 | 83 of 416 | 20.0 | 36 of 380 | 9.5 | 2.08 | 1.40 to 3.07 |
| ≥ 60 | 50 of 187 | 26.7 | 22 of 140 | 15.7 | 1.47 | 0.89 to 2.42 |
| Men | ||||||
| All ages | 80 of 250 | 32.0 | 39 of 234 | 16.7 | 1.90 | 1.30 to 2.79 |
| < 45 | 25 of 92 | 27.2 | 19 of 108 | 17.6 | 1.30 | 0.72 to 2.37 |
| ≥ 45 | 55 of 158 | 34.8 | 20 of 126 | 15.9 | 2.35 | 1.41 to 3.93 |
| ≥ 60 | 30 of 64 | 46.9 | 9 of 55 | 16.4 | 3.08 | 1.46 to 6.51 |
| CPTC | ||||||
| All patients | ||||||
| All ages | 168 of 813 | 20.7 | 79 of 635 | 12.4 | 1.75 | 1.34 to 2.29 |
| < 45 | 64 of 368 | 17.4 | 46 of 345 | 13.3 | 1.26 | 0.86 to 1.85 |
| ≥ 45 | 104 of 445 | 23.4 | 33 of 290 | 11.4 | 2.33 | 1.57 to 3.46 |
| ≥ 60 | 56 of 193 | 29.0 | 18 of 111 | 16.2 | 1.90 | 1.11 to 3.24 |
| Women | ||||||
| All ages | 104 of 612 | 17.0 | 50 of 501 | 10.0 | 1.74 | 1.24 to 2.44 |
| < 45 | 43 of 296 | 14.5 | 30 of 281 | 10.7 | 1.35 | 0.84 to 2.16 |
| ≥ 45 | 61 of 316 | 19.3 | 20 of 220 | 9.1 | 2.23 | 1.34 to 3.70 |
| ≥ 60 | 34 of 143 | 23.8 | 13 of 81 | 16.0 | 1.41 | 0.74 to 2.70 |
| Men | ||||||
| All ages | 64 of 201 | 31.8 | 29 of 134 | 21.6 | 1.70 | 1.09 to 2.65 |
| < 45 | 21 of 72 | 29.2 | 16 of 64 | 25.0 | 1.01 | 0.53 to 1.95 |
| ≥ 45 | 43 of 129 | 33.3 | 13 of 70 | 18.6 | 2.47 | 1.32 to 4.63 |
| ≥ 60 | 22 of 50 | 44.0 | 5 of 30 | 16.7 | 3.90 | 1.47 to 10.32 |
| FVPTC | ||||||
| All patients | ||||||
| All ages | 19 of 89 | 21.4 | 24 of 342 | 7.0 | 2.76 | 1.51 to 5.06 |
| < 45 | 6 of 35 | 17.1 | 15 of 175 | 8.6 | 2.06 | 0.79 to 5.38 |
| ≥ 45 | 13 of 54 | 24.1 | 9 of 167 | 5.4 | 3.50 | 1.49 to 8.23 |
| ≥ 60 | 8 of 16 | 50.0 | 4 of 60 | 6.7 | 3.43 | 0.97 to 12.13 |
| Women | ||||||
| All ages | 12 of 70 | 17.1 | 21 of 266 | 7.9 | 2.17 | 1.06 to 4.45 |
| < 45 | 4 of 28 | 14.3 | 15 of 143 | 10.5 | 1.43 | 0.47 to 4.36 |
| ≥ 45 | 8 of 42 | 19.0 | 6 of 123 | 4.9 | 3.50 | 1.21 to 10.12 |
| ≥ 60 | 5 of 12 | 41.7 | 3 of 41 | 7.3 | 4.86 | 0.90 to 26.37 |
| Men | ||||||
| All ages | 7 of 19 | 36.8 | 3 of 76 | 4.0 | 5.60 | 1.44 to 21.76 |
| < 45 | 2 of 7 | 28.6 | 0 of 32 | 0.0 | * | |
| ≥ 45 | 5 of 12 | 41.7 | 3 of 44 | 6.8 | 2.71 | 0.64 to 11.45 |
| ≥ 60 | 3 of 4 | 75.0 | 1 of 19 | 5.3 | 2.18 | 0.17 to 28.05 |
Abbreviations: CPTC, conventional papillary thyroid cancer; FVPTC, follicular-variant papillary thyroid cancer; HR, hazard ratio; PTC, papillary thyroid cancer.
*
Could not be estimated.