Fig 4.

Clinical and immunologic responses to recombinant human interleukin-15 (rhIL-15) infusions. For patients administered rhIL-15 (A) 3, (B) 1, or (C) 0.3 μg/kg, mean arterial pressure (MAP; upper panels) and temperature (middle panels) are shown as mean ± SEM after 12 daily infusions of rhIL-15 for one patient in each group; plasma cytokine concentrations are shown as mean ± SEM for all patients in each group after first infusion (lower panel). Fever, rigors (occurring within 2.5 to 4 hours), and hypertension followed by hypotension occurred contemporaneously with elevations in IL-6 and interferon gamma (IFN-γ). TNF-α, tumor necrosis factor alpha.