Fig A2.

Dose effect on lymphocyte dynamics during and after daily interleukin-15 (IL-15) infusions. All data shown as mean for administration of IL-15 3 μg/kg (n = 4) or 0.3 μg (n = 9). All fold-change values were computed by individual relative to baseline (Pre). Light blue bars indicate IL-15 infusion time. Error bars were omitted for clarity. (A) Representation within natural killer (NK) cells and (B) proliferation state of differentiation stages of NK cells. (C) Absolute CD4 and CD8 T-cell counts. (D) Absolute counts of CD8 differentiation stages. (E) Absolute counts of γδ T-cell lineages. Activation and proliferation states of (F) CD8 and (G) CD4 cells based on any of four markers. (H) Absolute counts and (I) representation (frequency within total CD4 T cells) of T regulatory cells.