Table A2.

Summary of Clinical Features of Patients Receiving rhIL-15 3.0, 1.0, and 0.3 μg/kg per Day

Feature	Patient Age (years)	Sex	No. of Doses	Maximum-Fold Increase ALC From Baseline	Platelets (× 103/mm3)		Absolute Neutrophil Count				Maximum ALT/AST
					Start	Nadir	Start	Nadir	Days < 1,000/mm3	Days < 1,500/mm3	ALT	AST
3 μg/kg
Melanoma	83	F	1	NC		NC		NC	0		NC	NC
Ocular melanoma	43	M	12	1.8	568	187	9,270	2,750	0		52	49
Melanoma	53	M	10	4.2	672	157	4,130	2,370	0		99*	120*
Ocular melanoma	57	F	12	2.4	296	97	4,560	1,360	0		36	118
Melanoma	34	M	6	3.8	176	44†	3,940	1,020	0		29	38
1 μg/kg
Renal cell	57	M	4	2.3	207	129	5,520	1,430	0		232†	128†
Renal cell	67	M	12	1.9	265	166	4,680	1,270	0		49	59
Melanoma	21	F	12	2.2	617	239	4,810	1,110	0	1	19	41
Mucosal melanoma	50	M	4	1.3	312	120	6,420	590‡	1	2	465†	399†
0.3 μg/kg
Melanoma	68	F	12	1.5	338	167	4,630	930‡	2	6	41	48
Melanoma	66	F	12	1.4	251	110	2,680	870‡	4	11	102*	85*
			6	NC	206	127	2,530	930‡	1	5	67	52
Renal cell	71	M	12	3.2	177	92	3,500	930‡	0	9	82	64
			12	1.3	155	95	2,760	930‡	0	3	68	48
Renal cell	43	M	12	1.7	199	118	5,450	1,930	0		38	27
Renal cell	47	M	12	1.3	176	108	3,970	2,230	0		51	40
			12	1.8	173	111	4,520	2,680	0		36	33
Renal cell	61	F	12	1.4	168	111	2,860	560‡	8		190*	241*
			12	1.3	176	128	1,620	460‡	11		118*	121*
Melanoma	74	F	12	2.5	288	145	8,750	1,850	0		27	28
			12	1.1	294	191	3,450	2,260	0		22	23
Renal cell	33	F	12	2.1	204	122	2,580	750‡	1	7	20	53
			6	NC	219	132	3,890	1,110	0	4	19	16
Mucosal melanoma	44	F	12	1.3	317	148	5,060	1,790	0		58	57

Abbreviations: ALC, absolute lymphocyte count; NC, no change; rhIL-15, recombinant human interleukin-15.

^*Notable transaminase result.

^†Dose-limiting toxicity.

^‡Notable neutrophil count.