. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: J Neurovirol. 2014 Sep 17;20(6):603–611. doi: 10.1007/s13365-014-0284-0

Table 2.

Associations (t values^a) between metabolic factors and brain volumes within single (S) and multiple (M) metabolic variable models.

	Abnormal White	Total White	Cortical Gray	Subcortical Gray	Ventricular Fluid	Sulcal Fluid
BMI (S)	−0.58	4.23****	−4.09****	−0.53	−1.43	−0.64
BMI (M)	−0.90	3.76^***	−4.16****	−0.43	−1.55	−0.08
Cholesterol (S)	0.10	1.29	−2.27^*	−1.81	1.20	0.33
LDL-C (S)	−0.15	2.53^*	−1.33	−1.05	−0.17	−1.67⁺
LDL-C (M)	−0.09	1.67	−0.44	−0.96	0.17	−1.59
HDL-C (S)	0.09	−1.71	−1.25	−1.79	1.80	2.42^*
HDL-C (M)	−0.21	−1.50	−1.68	−1.95	2.01^*	2.41^*
Glucose (S)	2.71^**	−0.27	−0.02	−0.57	1.33	0.71
Glucose (M)	1.91	0.06	−0.01	−0.12	0.25	0.51
Diabetes (S)	2.32^*	1.10	0.66	0.63	2.43^*	0.58
Diabetes (M)	1.39	1.72	0.87	0.71	2.51^*	0.54

Parameter estimates shown are t values from the multivariable regression models, and statistically significant associations are indicated in bold with p values linked to the number of asterisks

=p<.05,

^**

=p<.01,

^***

=p<.001

All models included control variables of scanner, age, gender, ethnicity, CD4 nadir, and supratentorial cranial vault. Multiple metabolic variable models (M) also included BMI, HDL-C, LDL-C, Glucose, Diabetes. Abbreviations: BMI=body mass index, C-LDL= low-density lipoprotein, C-HDL= high-density lipoprotein.