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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Bone. 2014 Aug 28;70:62–65. doi: 10.1016/j.bone.2014.07.026

Figure 2.

Figure 2

a. Representative sections of the trabecular bone of young adult mice treated with either Placebo (PBS) or LLP2A- Ale, with three monthly injections. LLP2A treatments significantly increased the number of osteoblasts on the trabecular bone surface and new bone bridges were formed between the trabeculae (blue arrows). Figure 2B is a coronal bone section of the proximal tibial metaphyses from an osterix mCherry red reporter mouse. Treatment with LLP2A- Ale increased osteoblast number and activity on the periosteal surface (yellow arrow) and this was not seen in the PBS treated mice. Figure 3C is a cross-section of the mid- tibial shaft. Treatment with LLP2A- Ale resulted in new bone formation on the periosteal surface (green arrow) and this was not observed in the PBS treated mice.