Table 3.

Neonatal dosing relative to adult intravenous dosing regimens

Drug	Age Group (ref)	Interval Dose	Adult Interval Dose Normalized to 70 kg Adult (ref)	Neonatal Total Daily Dose	Adult Total Daily Dose	Fold Change (neonate to adult)
Metronidazole	<34 weeks PMA (50, 53)	7.5 mg/kg every 12 h	7.5 mg/kg every 6 h (67)	15 mg/kg	30 mg/kg	2
Piperacillin-tazobactam	≤30 weeks PMA (60)	100 mg/kg every 8 h	65 mg/kg every 6 h (68)	300 mg/kg	260 mg/kg	0.87
Meropenem	≥32 weeks GA, ≥14 days PNA (64)	30 mg/kg every 8 h	15 mg/kg every 8 h (69)	90 mg/kg	45 mg/kg	0.5

GA, gestational age; PMA, postmenstrual age; PNA, postnatal age.