1. |
Loss of polarity of basal cells |
2. |
More than one layer of cell with basaloid appearance |
3. |
Drop-shaped rete-ridges |
4. |
Increased nuclear-cytoplasmic ratio |
5. |
Nuclear hyperchromatism |
6. |
Enlarged nucleoli |
7. |
Increased number of mitotis |
8. |
Abnormal form of mitosis |
9. |
The presence of mitotic cells in the superficial epithelium |
10. |
Cellular and nuclear pleomorphism |
11. |
Irregular epithelial stratification |
12. |
Loss of intercellular adherence |
13. |
Keratinization of single cells or cell groups in the prickle cell layer |