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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Invest Dermatol. 2014 Aug 22;135(1):170–180. doi: 10.1038/jid.2014.310

Fig. 5. Pseudoainhum (autoamputation) in TAM67-expressing mice.

Fig. 5

SKH1-TAM67-rTA mice were treated for 21 d with 2 mg/ml doxycycline and the doxycycline was then removed for 7 or 11 d. A/B Appearance of mice at 7 and 11 d after discontinuation of doxycycline treatment. The accumulated cornified material is progressively shed from the skin surface. The arrows indicate the remaining cornified material and a residual scar. C/D Appearance of the tails of two mice after 21 d doxycycline treatment followed by 11 d without doxycycline. The arrows show representative pseudoainhum bands on each tail. In some mice the tail is lost due to autoamputation. E An immunoblot showing TAM67- FLAG level in 21 d doxycycline treatment mice versus mice treated for 21 d followed by 7 d of discontinued treatment. F Early stage pseudoainhum of digits in mouse treated for 21 d with doxycycline. The arrow indicats pseudoainhum-associated edema.