Table 1.
Summary of HK isoforms, metabolic profiles, susceptibility to I/R injury and ability to protect by IPC in different settings.
Tissue | Predominant HK isoform | Metabolic Profile | Susceptibility to I/R injury | Protection by IPC | ||
---|---|---|---|---|---|---|
Glycolysis | Glu Ox | FA Ox | ||||
Adult heart | HK2 | Low | Low | High | High | High |
Cancer cells | HK2 | High | Low | Low | Low | ? |
Fetal/Neonatal heart | HK1 | High | High | Low | Low | Low |
Hypertrophied adult heart | HK2 | High | Low | Low | High | High |
Failing adult heart | HK2 | Low | Low | Low | Low? | Low? |
Diabetic adult heart | HK1 | Low | Low | High | Low (short term diabetes) | Low |
High (long term diabetes) |
FA= fatty acid; Glu=glucose; Ox=oxidation