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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2014 Sep 26;0:107–115. doi: 10.1016/j.yjmcc.2014.09.020

Table 1.

Summary of HK isoforms, metabolic profiles, susceptibility to I/R injury and ability to protect by IPC in different settings.

Tissue Predominant HK isoform Metabolic Profile Susceptibility to I/R injury Protection by IPC
Glycolysis Glu Ox FA Ox
Adult heart HK2 Low Low High High High
Cancer cells HK2 High Low Low Low ?
Fetal/Neonatal heart HK1 High High Low Low Low
Hypertrophied adult heart HK2 High Low Low High High
Failing adult heart HK2 Low Low Low Low? Low?
Diabetic adult heart HK1 Low Low High Low (short term diabetes) Low
High (long term diabetes)

FA= fatty acid; Glu=glucose; Ox=oxidation

HHS Vulnerability Disclosure