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. Author manuscript; available in PMC: 2015 Jun 11.
Published in final edited form as: Nature. 2014 Sep 28;516(7530):242–245. doi: 10.1038/nature13760

Figure 1. SVAs and L1PAs are de-repressed in a non-primate cellular environment.

Figure 1

a, KAP1, H3K4me3 ChIP-seq and RNA-seq coverage tracks for a selection of KAP1-bound primate-specific retrotransposons de-repressed in TC11-mESCs (yellow) relative to human ESCs (grey). H3K4me3 signal on promoters is similar in hESCs and TC11-mESCs. b, Percentages of SVA, L1Hs and L1PA elements on human chromosome 11 positive for KAP1, H3K4me3 (MACS ChIP-seq analysis) and arbitrary levels of transcription (see Methods) in hESC and TC11-mESCs. Total elements of each type on human chromosome 11 in parentheses.