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. Author manuscript; available in PMC: 2015 Jun 11.
Published in final edited form as: Nature. 2014 Sep 28;516(7530):242–245. doi: 10.1038/nature13760

Figure 4. Dynamic patterns of co-evolution between ZNFs and target retrotransposons.

Figure 4

Schematic showing the evolution of L1PA9 and SVA8 retrotransposons parallel to the structural evolution of ZNF93 and ZNF91 along an evolutionary timescale. Red zinc fingers: deletion; blue zinc fingers: change in contact residues; green zinc fingers: duplication. Coloring of ZNF91/ZNF93 horizontal bars: Zinc finger changes (changes in DNA-contacting residues, zinc finger deletions and duplications)/myr during the time interval indicated. Coloring of TE horizontal bars: basepair substitutions/deletions/insertions per site/myr (L1PA), or percentage increase in VNTR size/myr (SVA). myr = million years; owm = old world monkey