Table 5.
Odds ratios (OR) of SLICC renal involvement a in patients with SLE (N=308) by antibody patterns, adjusted for demographics (age, ethnicity and gender)
| Serologic patterns | N (308) | SLICC renal (OR*) | 95% CI | p-value | ||
|---|---|---|---|---|---|---|
| Anti-C1q | Anti-dsDNA | Low Complement | ||||
| Negative (ref.) b | Negative | Negative | 75 | 1.00 | ||
| Negative | Negative | Positive | 41 | 1.83 | 0.62 – 5.34 | 0.27 |
| Negative | Positive | Negative | 35 | 2.46 | 0.79 – 7.61 | 0.12 |
| Negative | Positive | Positive | 71 | 5.23 | 2.10 – 13.05 | <0.01 |
| Positive | Negative | Negative | 6 | 4.06 | 0.60 – 27.30 | 0.15 |
| Positive | Negative | Positive | 13 | 0.66 | 0.07 – 6.11 | 0.72 |
| Positive | Positive | Negative | 9 | 5.74 | 1.16 – 28.29 | 0.03 |
| Positive | Positive | Positive | 58 | 14.89 | 5.77 – 38.44 | <0.01 |
a
SLICC renal involvement is defined as urine protein-to-creatinine ratio (or 24-hour urine protein) representing 500mg/24 hours or red blood cell casts; estimates of odds ratios (OR) are from multivariable logistic regression model, constant term 0.95, 95% CI 0.26 - 3.49, p-value 0.94)
b
ref. denotes the reference group for each category