Skip to main content
. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Drug Alcohol Depend. 2014 Oct 20;0:156–167. doi: 10.1016/j.drugalcdep.2014.10.007

Table 1.

Summary of the five randomized clinical trials comprising the aggregate sample.

Study characteristics Study A Study B Study C Study D Study E
Patient sample Cocaine dependent with co-morbid alcohol dependence Cocaine dependent Cocaine dependent stabilized on methdaone maintenance Cocaine dependent Cocaine dependent
N; female N(%) 91; 26 (28.6) 108; 27 (25.0) 112; 46 (41.1) 38; 18 (47.4) 85; 26 (30.6)
Treatment duration 12 weeks 12 weeks 12 weeks 8 weeks 12 weeks
Urine screen frequency during treatment 1 week 1 week 3 week 2 week 3 week
Follow-up duration 12 months 12 months 12 months 6 months 12 months
Treatment cells1 CBT + DSF CBT + DSF TSF + DSF CBT4CBT + TAU CBT + CM + DSF
ClinM + DSF IPT + DSF TAU + DSF TAU CBT + DSF
CBT + No Meds CBT + PLAC TSF + PLAC CBT + CM + PLAC
TSF + No Meds IPT + PLAC TAU + PLAC CBT + PLAC
Primary outcome or follow-up cCitations Carroll et al. (2000), Carroll et al. (1998) Carroll et al. (2004) Carroll et al. (2012b) Carroll et al. (2008, 2009) Carroll et al. (under review)
1

CBT = clinician-delivered Cognitive Behavioral Therapy following the manualized guidelines for CBT for substance use disorders (Carroll, 1998); DSF = disulfiram (250mg/day); ClinM = clinical management (Carroll et al., 1998; O'Malley and Carroll, 1996); IPT = interpersonal therapy adapted for drug abuse (Rounsaville et al., 1985); PLAC = placebo capsule; TSF = twelve step facilitation (Baker, 1998); CBT4CBT = computer-delivered Cognitive Behavioral Therapy; TAU = treatment as usual in a community outpatient setting, including access to individual and group therapy sessions and urine screens; CM = prize-based contingency management (Carroll et al., 2012a; Petry et al., 2000).