Table 1.
Study characteristics | Study A | Study B | Study C | Study D | Study E |
---|---|---|---|---|---|
Patient sample | Cocaine dependent with co-morbid alcohol dependence | Cocaine dependent | Cocaine dependent stabilized on methdaone maintenance | Cocaine dependent | Cocaine dependent |
N; female N(%) | 91; 26 (28.6) | 108; 27 (25.0) | 112; 46 (41.1) | 38; 18 (47.4) | 85; 26 (30.6) |
Treatment duration | 12 weeks | 12 weeks | 12 weeks | 8 weeks | 12 weeks |
Urine screen frequency during treatment | 1 week | 1 week | 3 week | 2 week | 3 week |
Follow-up duration | 12 months | 12 months | 12 months | 6 months | 12 months |
Treatment cells1 | CBT + DSF | CBT + DSF | TSF + DSF | CBT4CBT + TAU | CBT + CM + DSF |
ClinM + DSF | IPT + DSF | TAU + DSF | TAU | CBT + DSF | |
CBT + No Meds | CBT + PLAC | TSF + PLAC | CBT + CM + PLAC | ||
TSF + No Meds | IPT + PLAC | TAU + PLAC | CBT + PLAC | ||
Primary outcome or follow-up cCitations | Carroll et al. (2000), Carroll et al. (1998) | Carroll et al. (2004) | Carroll et al. (2012b) | Carroll et al. (2008, 2009) | Carroll et al. (under review) |
CBT = clinician-delivered Cognitive Behavioral Therapy following the manualized guidelines for CBT for substance use disorders (Carroll, 1998); DSF = disulfiram (250mg/day); ClinM = clinical management (Carroll et al., 1998; O'Malley and Carroll, 1996); IPT = interpersonal therapy adapted for drug abuse (Rounsaville et al., 1985); PLAC = placebo capsule; TSF = twelve step facilitation (Baker, 1998); CBT4CBT = computer-delivered Cognitive Behavioral Therapy; TAU = treatment as usual in a community outpatient setting, including access to individual and group therapy sessions and urine screens; CM = prize-based contingency management (Carroll et al., 2012a; Petry et al., 2000).