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At 6 weeks post-tumor inoculation, tibias bearing LAPC-9 intratibial xenografts grossly show bone marrow displacement by the tumor and high-resolution ex vivo microCT demonstrates osteoblastic changes in the LAPC-9 injected tibias with normal appearing sham controls (A). Histology of LAPC-9 bearing tibias shows tumor interspersed with osteoblastic bone formation whereas histology of sham tibias shows normal bone marrow (B).
