Table 2.
Biodistribution of 124I-A11 minibody in mice bearing LAPC-9 xenografts at 44 hours post-injection show decreased uptake in MDV-3100 (40mg/kg) treated mice compared to vehicle control.
| Vehicle | MDV-3100 | ||||
|---|---|---|---|---|---|
| n | %ID/g±SD | n | %ID/g±SD | p | |
| LAPC-9 | 9 | 3.63±0.59 | 9 | 2.75±0.95 | 0.03 |
| Blood | 5 | 0.65±0.11 | 5 | 0.61±0.14 | 0.63 |
| Liver | 5 | 0.19±0.01 | 5 | 0.18±0.03 | 0.48 |
| Kidney | 5 | 0.26±0.03 | 5 | 0.26±0.08 | 0.95 |
| Heart | 5 | 0.32±0.06 | 5 | 0.25±0.05 | 0.08 |
| Lungs | 5 | 0.54±0.08 | 5 | 0.62±0.19 | 0.42 |
| Spleen | 5 | 0.27±0.04 | 5 | 0.36±0.11 | 0.15 |
| Stomach | 5 | 0.38±0.09 | 5 | 0.30±0.05 | 0.14 |
| Tail | 5 | 0.56±0.27 | 5 | 0.59±0.25 | 0.86 |
| Muscle | 5 | 0.05±0.02 | 5 | 0.05±0.01 | 0.92 |
| Carcass | 5 | 0.13±0.02 | 5 | 0.12±0.02 | 0.57 |
| Tumor:Blood | 9 | 5.58±1.07 | 9 | 4.51±1.32 | 0.08 |
| Tumor:Muscle | 9 | 74.0±29.1 | 9 | 53.6±17.7 | 0.09 |