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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Neurobiol Aging. 2014 Aug 30;36 Suppl 1:S203–S210. doi: 10.1016/j.neurobiolaging.2014.01.154

Figure 2. Homocysteine levels are related to regional cortical GM volumes.

Figure 2

Whole brain 3D maps of significant associations between homocysteine levels and regional cortical gray matter (GM) volumes in the left and right hemispheres of all N=803 subjects, (A) after controlling for age and sex (left: −log10(p-value)=1.673–3.930, right: −log10(p-value)=1.663–3.920, FDR corrected) and (B) after controlling for age, sex, and diagnosis (AD, MCI, or healthy elderly) (left: −log10(p-value)=2.204–4.462, right: not significant, FDR corrected). Results were corrected for multiple comparisons by thresholding at a p=0.05 false discovery rate (FDR) threshold across the entire brain surface. Blue areas represent points on the cortical surface where p-values passed the corrected significance threshold for a negative relationship between homocysteine levels and cortical GM volumes (higher levels of homocysteine associated with lower cortical GM volumes). No areas of significant positive associations were found.