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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Cancer Res. 2014 Oct 27;74(24):7357–7370. doi: 10.1158/0008-5472.CAN-14-0666

Fig 1. Increased expression of SIX2 in human breast cancers correlates with poor prognosis.

Fig 1

(A) SIX2 mRNA expression was determined by real-time PCR and normalized to CYCLOPHILIN in three normal mammary epithelial cell lines and eight human breast cancer cell lines. (B) SIX2 mRNA expression in human breast cancers compared to normal breast tissue in Richardson breast2 and TCGA breast data sets from Oncomine. Oncomine™ (Compendia Bioscience, Ann Arbor, MI) was used for analysis and visualization. (C) Top quartile SIX2 expression predicts poor prognosis in human breast cancers. Kaplan-Meier curves show that SIX2 expression correlates with distant metastasis free (DMFS), relapse free survival (RFS), and overall survival (OS). (D) Top quartile SIX2 expression predicts poor prognosis in luminal A breast cancer. Kaplan-Meier curves demonstrate that SIX2 expression correlates with distant metastasis free survival (DMFS), relapse free survival (RFS) and overall survival (OS) in luminal A tumors by HU-gene expression subtype (45). Data was extracted from the GOBO website (http://co.bmc.lu.se/gobo).